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Other medications make a difference in removing acetaminophen from the body, which may have an impact on how hydrocodone/acetaminophen works. For example azole antifungals (like ketoconazole), macrolide antibiotics (like erythromycin), HIV medications (like ritonavir), rifamycins (like rifampin, rifabutin), certain drugs used to take care of seizures (like carbamazepine, phenytoin), amongst others.
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